Border Region, Indonesian Border, Nusa Tenggara Timur, Poverty Problems, Timor Leste This paper wants to see the poverty problems and the causative factors in the Indonesian border region in the Nusa Tenggara Timur Province (NTT). The research method used by examining some literature and using quantitative descriptions with data sources is secondary data. The data obtained came from the Ministry of National Development Planning/Bappenas. The research of border areas is Belu Regency, Timor Tengah Utara, Kupang Regency, Malaka Regency, and Alor Regency. From the data findings, the entire border region must get priority attention, especially in Malaka and Alor Regency. When comprehensively viewed from various aspects, the NTT Province has an excellent opportunity to get out of poverty. The geographic position of NTT as an international gateway for Eastern Indonesia has political and economic aspects that have strong selling points. Also, marine natural resources that have not been explored and have not been adequately managed have the potential to support the economy of NTT.