Adult learners, Distance learning, NOUN, Programmes. The paper examines experience of adult learners in distance learning programme of National Open University of Nigeria, Oyo State Centre. Descriptive research method was adopted for the study. Structured questionnaire were designed to gather information from learners of NOUN in Oyo State. Data collected were analysed using frequency counts and simple percentage. The results of the study showed that experience of adult learners in distance learning programme have either positive or negative effects on their studies. Findings revealed that adequate and inadequate infrastructures affect the experience of adult learners in distance learning of NOUN. Findings of the study also indicated that there were measures put in place that could be used to improve the effect of experience on adult learners academic performance(s). The study recommended that Ministry of Education and NUC should monitor National Open University and accredit all the programmes. The staff of NOUN should be more proactive in rendering their services. Distance education fees should be reduced by the government. Lecturers and learners of NOUN programmes should have place for face-to-face interaction to enhance academic performance.